Wednesday, 17 July 2013

China bars Glaxo exec from leaving country

China has barred a GlaxoSmithKline executive from leaving the country as it turns up the heat on the drugmaker over allegations of corruption.

Steve Nechelput, finance director for GlaxoSmithKline China, has been prevented from traveling outside China since the end of June, the company said Wednesday.

The U.K. drugmaker has been accused by China of using a network of more than 700 travel agencies and other firms to channel bribes to health officials since 2007.

Four senior Chinese executives of GSK have been detained, according to state news agency Xinhua, although the company says Nechelput was not among them.

"At no time has [Nechelput] been questioned or arrested, and he is not one of the individuals in detention," a GSK spokesperson said.

Nechelput, who holds a British passport, remained in his post. Mark Reilly, the top GSK executive in China, is currently in the U.K.

Meanwhile, Chinese state media has put the government's allegations against GlaxoSmithKline on public display.

The company was the subject of an editorial published Wednesday in the Communist Party's mouthpiece publication, and state central television aired the apparent confession of one of the four GSK executives.

The media campaign is the latest in a series of actions in recent days that suggest China is embarking on a concerted effort to crack down on corruption.

The commentary in the People's Daily was written under a pseudonym -- but one that sounds like "voice of China" when spoken.

"GlaxoSmithKline's bribery case shows how complicated and difficult the fight against commercial corruption can be," the commentary said. "Seriously attacking multinational companies' commercial bribery is of great significance to maintaining market economy order and keeping a fair competition environment."

GSK (GSK) is accused of funneling hundreds of millions of dollars in kickbacks to doctors, hospital and government officials in China. The activities appear to have been designed to encourage the use of GSK products, and to keep prices at artificially high levels.

Related story: China drugs scandal set to grow 

The CCTV report featured GSK executive Liang Hong explaining how the bribery scheme worked, including the use of fake conferences and travel agencies to create receipts for services that were never performed. The surplus funds were then used to pay bribes.

The circumstances of the interview are difficult to discern and it wasn't clear whether the confession was coerced.

How much damage the scandal will do to GSK's reputation or bottom line remains unclear. But the episode underscores the challenges of doing business in China, an enormous, rapidly developing market in which bribes and corruption are often deeply ingrained.

Related story: Rolls-Royce in China corruption probe

GlaxoSmithKline -- which makes Paxil, Avandia and Wellbutrin -- declined to comment on the CCTV report and reiterated a statement from earlier this week that it was "deeply concerned and disappointed" by the allegations.

"GSK shares the desire of the Chinese authorities to root out corruption," a spokesperson said Monday. "These allegations are shameful and we regret this has occurred."

China's investigation could expose the company to legal action in the U.K., and possibly the United States, under laws relating to the bribery of foreign public officials.

GlaxoSmithKline said it had informed the U.K.'s Serious Fraud Office about the allegations but had not yet been asked to provide any further information. The agency, which investigates and prosecutes corruption cases, said it could neither confirm nor deny an interest in the claims against GSK at this stage.

Asked about Nechelput's travel restrictions, the U.K. Foreign Office said it was seeking more information from the Chinese authorities and was in contact with GSK.

Swedish Study Suggests Bipolar Disorder Associated With Premature Mortality

Bipolar disorder was associated with premature mortality in a large study of Swedish adults by Casey Crump, M.D., Ph.D., of Stanford University, California, and colleagues.

The study used outpatient and inpatient data from more than 6.5 million Swedish adults, including 6,618 with bipolar disorder, to examine the physical health effects associated with bipolar disorder. Bipolar disorder is a chronic mental illness and a leading cause of disability worldwide.

According to the results, women and men with bipolar disorder died nine and 8.5 years earlier on average, respectively, than the rest of the population. All-cause mortality was increased two-fold among women and men with bipolar disorder compared to the rest of the population. Patients with bipolar disorder also had increased mortality from cardiovascular disease, diabetes mellitus, chronic obstructive pulmonary disease (COPD), influenza or pneumonia, unintentional injuries and suicide for both women and men, and cancer for women only.

"Timely medical diagnosis appeared to improve chronic disease mortality among bipolar disorder patients to approach that of the general population. More effective provision of primary, preventive medical care is needed to reduce early mortality among persons with bipolar disorder," the study concludes.

Quote of the day


"Today, nearly 40 percent of a senior's healthcare spending is on pharmaceutical medications"

Dennis Hastert
American politician

Monday, 15 July 2013

Lynn Evans: Drop boxes part of prescription drug abuse battle

The Centers for Disease Control calls it an epidemic. The Mississippi Department of Public Safety calls it Mississippi’s No. 1 drug threat. Prescription drug abuse is killing men and women from all walks of life. The CDC reports that the deaths of women from prescription drugs has risen most dramatically: about 400 percent since 1999. Marshall Fisher of the Mississippi Bureau of Narcotics estimates that 90 percent of the 206 drug overdose deaths in this state in 2012 were due to the abuse of prescription narcotics.

Prescription narcotics, especially opioids such as Oxycontin and hydrocodone, are almost always prescribed for chronic pain — but medical science now shows that opioids are not a reliable treatment for noncancerous chronic pain. In other words, they mask but do not stop the pain.

The CDC reports that the sale of opiate pain relievers has increased by 300 percent since 1999. In 2008, there were more U.S. deaths from opiate pain relievers that from cocaine and heroin combined.

The misuse of prescription painkillers cuts across all social strata and is becoming as big a public health problem for people in the prime of life as heart disease and cancer. The CDC estimates that for every death due to prescription painkillers, there are 32 visits to the emergency room, 130 people who are addicted users, and 825 people who are so-called nonmedical users — people taking prescription painkillers without a medical reason. The total cost is staggering: about $28 billion for the estimated 40 million Americans with addiction.

Opiates, as well as the other commonly abused drugs such as benzodiazepines (Valium, Xanax, Ativan) and ADHD-treating drugs like Adderall and Ritalin, can be incredibly addictive. Although only some 12 percent to 20 percent of people who ever use these drugs become addicted, once addicted their brain chemistry has changed enough to overrule all reason and social pressure telling them to stop. Addiction is a disease that can both rule and ruin the addict’s life because it affects the production of dopamine, the brain’s “happy juice.” For that reason, the best way to stop prescription pain medication abuse is not to take it for non-cancer pain in the first place.

Fertility treatment and risk of childhood and adolescent mental disorders: register based cohort study

An issue published by BMJ the risk of fertility treatment over childhood and adolescents. 

In conclusion, there was a small increase in the incidence of mental disorders in children born after ovulation induction/intrauterine insemination. Children born after in vitro fertilisation/intracytoplasmic sperm injection were found to have overall risk comparable with children conceived spontaneously.

Retirada de productos con yohimbina, el afrodisíaco natural

La Agencia Española de Medicamentos y Productos Sanitarios (AEMPS) ha retirado productos con yohimbina, a través de una denuncia procedente del Cuerpo Nacional de Policía de la venta de los productos relacionados en la siguiente tabla como complementos alimenticios a base de plantas medicinales de origen natural, cuya comercialización no ha sido notificada como tal a la Agencia Española de Seguridad Alimentaria y Nutrición, de acuerdo con lo previsto en la normativa vigente.

Según los análisis llevados a cabo por el Laboratorio Oficial de Control de la Agencia Española de Medicamentos y Productos Sanitarios, los mencionados productos contienen el principio farmacológicamente activo yohimbina. Estos productos declaran la presencia de la planta “yohimbe” en su etiquetado.

La inclusión de este principio farmacológicamente activo les conferiría la condición legal de medicamento según lo establecido en el artículo 8 de la Ley 29/2006, de 26 de julio, de garantías y uso racional de los medicamentos y productos sanitarios.

La yohimbina es un antagonista α2 adrenérgico (simpaticolítico). A dosis débiles es hipertensor y a dosis más elevadas hipotensor, vasodilatador de los territorios vasculares periféricos. La vasodilatación inducida en los cuerpos cavernosos es la causante de su capacidad para mejorar la función sexual. También provoca un aumento del tono y motilidad intestinal así como un aumento de la lipólisis en el adipocito. Debido a su actividad farmacológica a estos niveles ha sido utilizada en algunos productos pretendidamente comercializados como complementos alimenticios.

En España no hay ningún medicamento autorizado que contenga esta sustancia en su composición. Sin embargo, en Francia está autorizado un medicamento que tiene como indicación el tratamiento de la disfunción eréctil y de la hipotensión ortostática. La ficha técnica del producto en Francia recoge una serie de acontecimientos adversos relacionados con su uso, que incluyen: trastornos del sistema nervioso central (SNC) como nerviosismo, irritabilidad, insomnio, temblor, vértigo, migraña; problemas digestivos como náuseas, vómitos y/o diarreas; problemas cardiovasculares tales como taquicardia, priapismo. También presenta interacciones medicamentosas con clonidina e inhibición de la actividad de los medicamentos antihipertensivos.

Según la información disponible se desprende que estos productos se comercializan a través de internet así como en establecimientos fuera del canal farmacéutico. ¿Hay que estar dentro del canal farmacéutico para comercializar productos naturales?

Considerando lo anteriormente mencionado, así como que los citados productos no han sido objeto de evaluación y autorización previa a la comercialización por parte de la Agencia Española de Medicamentos y Productos Sanitarios, de acuerdo con lo dispuesto en el Real Decreto 1275/2011, de 16 de septiembre, por el que se crea la Agencia estatal "Agencia Española de Medicamentos y Productos Sanitarios" y se aprueba su Estatuto y el artículo 9.1 de la Ley 29/2006, de 26 de julio, siendo su presencia en el mercado ilegal, esta Dirección de la Agencia Española de Medicamentos y Productos Sanitarios, conforme a lo establecido en el artículo 99 de la citada Ley y en relación con el mencionado Real Decreto, ha resuelto ordenar que se proceda a la retirada del mercado de todos los ejemplares de los citados productos.

Quote of the day


"La salud de todo el cuerpo se fragua en la oficina del estómago"

Miguel de Cervantes
Poeta y dramaturgo español