Showing posts with label Ibuprofen/Iso-butyl-propanoic-phenolic acid. Show all posts
Showing posts with label Ibuprofen/Iso-butyl-propanoic-phenolic acid. Show all posts

Friday, 28 June 2013

Overuse of Common Painkiller May Increase Health Risk

Millions of Americans take ibuprofen or naproxen for pain relief. They are the go-to drugs for headaches, pulled muscles, arthritis and menstrual cramps.

New findings suggest those common painkillers, called non-steroidal anti-inflammatory drugs or NSAIDs, increase the risk of heart attack or stroke risk if taken in high doses. Brands like Motrin and Advil contain these drugs.

In 2004, Vioxx, Bextra and Celebrex were found to increase the risk of heart attacks and strokes, and they were pulled from the market.

Dr. Tara Narula, associate director of Lenox Hill Hospital's cardiac care unit, told "CBS This Morning: Saturday" that the people who have to worry are those who use these drugs more than the recommended over-the-counter dose. Consumers with chronic diseases such as osteo-arthritis or rheumatoid arthritis should be careful.

The labels warn about overuse, but a new study quantifies the actual risk.

"The latest research looked at several hundred thousand patients, 300,000, and what they found is that if 1,000 patients take it for a year, three are at risk for having a heart attack, one of which can be fatal," said Narula. "So these medications taken in high doses can be exactly as risky and dangerous as those removed from the market."

Narula said that short-term use of NSAIDs should be fine as it is actually overusing the drugs that is a problem.

However, there are also a few other pain relievers that can be safer. Acetaminophen, which is the drug in Tylenol, as well as opium-based drugs, such as morphine, might be good options depending on what you're treating. Each of these drugs has its own set of side effects, so before taking any of these drugs, it is important to consult with your doctor.

Wednesday, 19 June 2013

Codeína: El analgésico mortal para la infancia

La codeína es un opioide que, entre otras indicaciones, se encuentra autorizado como analgésico, bien como monofármaco o en combinación con otros principios activos (por ejemplo paracetamol, ibuprofeno o ácido acetil salicílico). Se usa básicamente como antitusígeno para niños.

La Agencia Española de Medicamentos (AEMPS) ha emitido una nota que alerta sobre las restricciones que deben haber en cuanto a su uso. Restricciones que hasta ahora, no había. Eso sí, se ha determinado su restricción en vez de su prohibición.

El efecto farmacológico de la codeína se debe a su transformación en morfina a través de la enzima CYP2D6 del citocromo P450. Existen diferencias genéticas en cuanto a la expresión de esta enzima que determinan el grado de esta metabolización. Así las personas con deficiencia en la enzima CYP2D6 obtendrán un menor efecto analgésico mientras que aquellas que tengan más de dos copias del gen que la codifica (metabolizadores ultra-rápidos) transformarán la codeína en morfina más rápidamente y por tanto tendrán más posibilidades de presentar reacciones adversas derivadas de la intoxicación por morfina.

La misma agencia ha reconocido que han muerto niños tras ser tratados con este medicamento.

“Codeína es considerado como un narcótico pero con bajos niveles de adicción” (…) La codeína es considerada una prodroga, ya que se metaboliza dando morfina”.